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HERDIN Record #: R07-CDU-13071111264737 Submitted: 11 July 2013 Modified: 27 September 2013

The effect of Allium sativum (Garlic) on the blood pressure and cholesterol levels of selected Filipino residents in Cebu province

Jeanne Michelle D. Amper,
Sharlene Y. Ang,
frankie Deo Detosil,
Vanessa Ediza,
Jestoni Joseph Estalilla,
Adrian Jayme Gabunada,
April Gacasan,
Kahty Garcia,
Kathryn Lace Geson,
Mark Joseph C. Labella,
Aiyana Michiko Lim,
Mark Seymour M. Mabalatan,
Vanessa Kathleen Ngochua,
Rizza Fe Patalinghug,
Sarah Jean Taganas,
Joseph Bernardo Li,
Emmalyn B. Cutamora,
Titus Bantiles

Objective: The study determined the effect of Allium sativum (Garlic) on the blood pressure and cholesterol levels of the selected Filipino residents in Cebu Province.

Setting: The study was conducted at the following barangays of Mandaue City - Mantuyong and Guizo. Barangays Capitol and Tejero in Cebu City and Barangay in Lapu-Lapu City.

Study Participants: With over 1000 individuals screened, 98 of those who were hypertensive and hypercholesterolemic were given treatment as participants. However, only 77 of the participants completed the 6 week course of treatment. They were screened by a physician before and after treatment administration. Twenty-six hypercholesteremic/hypertensive patients were supplied with garlic, and 25 with Simvastatin. The remaining 26 patients with high blood pressure were given Metoprolol, a proven regulator for blood pressure.

Procedures: A letter of request was sent to the Dean of the College of Allied Medical Sciences to conduct the study with the chosen Filipino residents of Cebu Province. Potential participants were screened by the researchers and a physician. Conventional drugs (Metoprolol and Simvastatin) were used to serve as a positive control to evaluate the extent of the garlic's effectiveness. Blood pressure, daily meal intakes, and any adverse reactions were strictly monitored. Patients were interviewed in order to determine variables that could have altered blood pressure/ cholesterol results. Blood cholesterol tests were taken the day before and after the six weeks treatment for comparison. The Anova and paired T-test equation were used to quantify the effect of all the three treatment groups.

Results: After 6 weeks of intervention, the participants who were treated by Garlic managed to reduce their systolic blood pressure from ¯x = 178.038 mm/Hg ± 24.18 (pre-treatment) to ¯x= 171.423 mm/Hg ± 24.394 (post-treatment) (P=.000) and diastolic ¯x= 93.692 mm/Hg ± 9.439 (pre) to ¯x= 90.962 mm/Hg ± 10.192 (post) (p-value=.004). Meanwhile, in the Metoprolol group, systolic blood pressure reduced from ¯x= 165.14 mm/Hg ± 23.474 to x¯ = 141.654 mm/Hg ± 18.208 (post) (p-value=.000). Diastolic blood pressure reduced from x¯ = 98.654 mm/Hg ± 10.737 (baseline) to ¯x= 89.731 mm/Hg ± 9.747 (post) (p=.000). Lastly, the Simvastatin group, systolic dropped from ¯x= 154.800 mm/Hg ± 29.736 to ¯x = 149.920 mm/Hg ± 25.895 (p-value=.008) and diastolic posted ¯x= 93.200 ± 15.885 (baseline) and ¯x = 89.000 mm/Hg ± 11.365 (post) (p-value=0.025). However, in cholesterol levels, garlic posted ¯x= 217.327 mg/dL ± 16.852 (pre) to ¯x= 220.815 mg/dL ± 24.360 (post) (p=.424). The Metoprolol group showed x¯ = 183.692 mg/dL ± 27.915 (pre) to ¯x= 188.615 mg/dL ± 22.590 (post) (p-value= .289). Simvastatin group started from ¯x= 233.560 mg/dL ± 32.146 (pre) to ¯x = 185.080 mg/dL ± 38.951 (post) of (p=.000).

Conclusion: The result of the study show that Allium sativum (garlic) causes a potential difference in lowering systolic and diastolic blood pressure while it did not reduce blood cholesterol levels.

Publication Type
Thesis/Dissertations
Thesis Degree
BS
Specialization
Medical Technology
Publication Date
January 2010

Objectives

Objective: The study determined the effect of Allium sativum (Garlic) on the blood pressure and cholesterol levels of the selected Filipino residents in Cebu Province.

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Citation

1. Review of regulatory policies on and benefits of herbal medicine in the Philippines.
2. Review of regulatory policies on and benefits of herbal medicine in the Philippines.
3. Review of regulatory policies on and benefits of herbal medicine in the Philippines.